The year 2020 has special significance. Nearly a decade ago in 2011, Eric Green and Mark Guyer of the U.S. National Human Genome Research Institute cited 2020 as a target milestone for human genomics research: beyond 2020, the goal was to have expanded from knowledge generation to greater emphasis on health applications that directly improve patient care. Important advances in our ability to generate and analyze data have brought us to this threshold of personalized, precision genomic medicine. I will discuss several studies in the addiction genetics field that exemplify effective strategies and tools that have brought us closer to this goal. These studies provide both results and resources that set the stage for the next decade of effort.